The three reliefs on the entrance wall are dedicated to the prayer and martyrdom of St Lorenzo and the stigmata of St Francis.

Eight large allegorical figures of Virtue are arranged along the longitudinal walls.

Two others, Charity and Hospitality, are placed on the sides of the arch that introduces the large chapel, on which the figure of St Francis receiving the cord of the Order.

The altar, with a marble and gilded bronze table, was created based on designs by Giacomo Amato.

On the back wall, flanked by pilasters and concluded by a curved tympanum, there was the Nativity created by Caravaggio in 1609 and stolen in 1969.

The church preserves valuable ebony wall seats inlaid with mother of pearl and other furnishings.

Until 1969, the year in which it was stolen, the main altar housed a valuable canvas painted by Caravaggio.

Recently the work returned to its place with a very faithful reproduction, created in a single example with techniques with very high technology capable of perfectly rendering every single detail of the original.